David Eric Worsley

Eric Lander and David Botstein on Mapping Quantitative Traits.

The rediscovery of Mendel’s work in the early 20th century sparked heated debate about the inheritance of continuously variable “size” traits (e.g., East 1916). But, although evidence accumulated in support ofMendelianmodels of quantitative trait inheritance, for most of the century it was rare for geneticists to be able to link such traits to specific Mendelian factors. The principles of mappi...

A Tribute to: Keith Worsley - 1951-2009

Legend has it that Keith's introduction to neuroimaging followed a chance encounter in a verdant corner of McGill University. One of us (Alan Evans) found Keith gatheringmaple leaves in the fond hope that variations in their shapewould provide a useful source of data, against which to test his statistical ideas. This was in the late 80s when PET scanners had just started producing images of cer...

Francis John Worsley Roughton, 1899-1972.

Eric Kandel

Organocatalysis Eric

T he field of asymmetric catalysis is dedicated to the development of efficient catalytic methods for the construction of chiral molecules and has been dominated by the use of organometallics and enzymes for most of its history. However, in the past decade, the concept of organocatalysis has emerged as a discrete strategy for addressing modern day challenges in chemistry. It has become widely a...